How does one go from odd beginnings to such extraordinary accomplishments? After Craig obtained the 2023 SynBioBeta Lifetime Achievement Award,…
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Environment friendly in vivo cytosine base enhancing utilizing virus-like particles with uracil DNA glycosylase inhibition – Nature Biotechnology
Wang, D., Zhang, F. & Gao, G. CRISPR-based therapeutic genome enhancing: methods and in vivo supply by AAV vectors. Cell…
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Retargeted serine integrases for one-step, exact integration of enormous DNA sequences in human cells – Nature Biotechnology
Urnov, F. D. et al. Extremely environment friendly endogenous human gene correction utilizing designed zinc-finger nucleases. Nature 435, 646–651 (2005).…
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Zero-shot de novo peptide sequencing with open posttranslational modification discovery – Nature Biotechnology
Aebersold, R. & Mann, M. Mass spectrometry-based proteomics. Nature 422, 198–207 (2003). Article CAS PubMed Google Scholar Dupree, E. J.…
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AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime enhancing – Nature Biotechnology
Laboratory-evolved RTs have lowered stability We beforehand utilized PACE to evolve RTs with enhanced exercise for prime enhancing, yielding variants…
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Directed evolution of small RNA-stabilizing motifs that enhance prime-editing effectivity – Nature Biotechnology
Basic molecular biology and cloning Primers had been ordered from Built-in DNA Applied sciences. All plasmids, together with self-targeting lentiviral…
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Widespread DNA off-targeting confounds RNA chromatin occupancy research – Nature Biotechnology
Cabili, M. N. et al. Integrative annotation of human massive intergenic noncoding RNAs reveals international properties and particular subclasses. Genes…
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Pure sunscreen present in fish eggs will be made by E. coli factories
Zebrafish produce the pure sun-blocking chemical gadusol WILDLIFE GmbH / Alamy A compound that protects clear fish eggs from the…
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Digital twins of ex vivo human lungs allow correct and personalised analysis of therapeutic efficacy – Nature Biotechnology
Human lung traits for DT growth The medical profiles of the human lungs used to develop the DT fashions are…
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Range-generating retroelements for programmable focused hypermutagenesis – Nature Biotechnology
Packer, M. S. & Liu, D. R. Strategies for the directed evolution of proteins. Nat. Rev. Genet. 16, 379–394 (2015).…
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