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AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime enhancing – Nature Biotechnology
Laboratory-evolved RTs have lowered stability We beforehand utilized PACE to evolve RTs with enhanced exercise for prime enhancing, yielding variants…
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Directed evolution of small RNA-stabilizing motifs that enhance prime-editing effectivity – Nature Biotechnology
Basic molecular biology and cloning Primers had been ordered from Built-in DNA Applied sciences. All plasmids, together with self-targeting lentiviral…
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Widespread DNA off-targeting confounds RNA chromatin occupancy research – Nature Biotechnology
Cabili, M. N. et al. Integrative annotation of human massive intergenic noncoding RNAs reveals international properties and particular subclasses. Genes…
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Pure sunscreen present in fish eggs will be made by E. coli factories
Zebrafish produce the pure sun-blocking chemical gadusol WILDLIFE GmbH / Alamy A compound that protects clear fish eggs from the…
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Digital twins of ex vivo human lungs allow correct and personalised analysis of therapeutic efficacy – Nature Biotechnology
Human lung traits for DT growth The medical profiles of the human lungs used to develop the DT fashions are…
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Range-generating retroelements for programmable focused hypermutagenesis – Nature Biotechnology
Packer, M. S. & Liu, D. R. Strategies for the directed evolution of proteins. Nat. Rev. Genet. 16, 379–394 (2015).…
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Useful integration of an autologous engineered esophagus in a large-animal mannequin – Nature Biotechnology
In vivo research design ARRIVE Pointers 2.0 have been adopted for research planning, conduct and writing. This was a single-arm…
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Extremely mutagenic steady evolution in E. coli utilizing a Φ29-based orthogonal replication system – Nature Biotechnology
Romero, P. A. & Arnold, F. H. Exploring protein health landscapes by directed evolution. Nat. Rev. Mol. Cell Biol. 10,…
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Agentic AI and the rise of in silico workforce science in biomedical analysis – Nature Biotechnology
Russell, S. & Norvig, P. Synthetic Intelligence: A Fashionable Method (Pearson Press, 2021). Turing, A. M. Computing equipment and intelligence.…
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