Hydroxyapatite toothpaste is a fluoride-free possibility that has some analysis backing its effectiveness.
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How you sweep your tooth — and what you utilize to do it — issues.

Just lately, dentist Dr. Jin-Ho Phark says he is observed sufferers asking about fluoride-free toothpaste choices. Phark is an affiliate professor of medical dentistry on the Herman Ostrow Faculty of Dentistry of College of Southern California.
“There’s lots of curiosity from the sufferers,” Phark says. “I hear that additionally usually from college students.”
One product that sufferers are asking about particularly is a calcium phosphate mineral known as hydroxyapatite. Many sufferers, Phark says, might have seen the merchandise on social media, “being pushed by influencers and different folks fairly intensively.”
The normal fluoride toothpaste turned frequent within the late Fifties, in accordance with the Facilities for Illness Management and Prevention, when Procter & Gamble Co. launched Crest nationally. Over the following few a long time, oral care merchandise with fluoride as their lively ingredient turned extensively obtainable around the globe. These merchandise assist shield the outer layer of tooth from cavity-causing micro organism.
And dental well being is vital as a result of it is associated to so many techniques in your physique, out of your coronary heart to digestion.
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“There are these connections made between your oral well being, and the bugs that you’ve in your mouth, and systemic well being and even the composition of your intestine microbiome,” says Dr. Livia Tenuta, a dentist who makes a speciality of stopping tooth decay and affiliate professor on the College of Michigan Faculty of Dentistry.
The declare
The promise of hydroxyapatite? Lots of the belongings you care about in relation to toothpaste: cavity safety, whitening, enamel-strengthening. However with out fluoride.
Well being consultants extensively agree that fluoride — a naturally occurring mineral — is useful to well being. However curiosity is rising about fluoride-free choices.
“There may be an growing variety of people who find themselves refusing fluoride completely, or hesitant to take it, particularly for his or her kids,” says Bennett Amaechi, a professor of dentistry on the College of Texas at San Antonio.
That hesitancy stems from a historical past of skepticism about fluoride. Well being Secretary Robert F. Kennedy Jr. has blamed the fluoridation of water for various well being issues, together with arthritis, bone fractures, bone most cancers, IQ loss, neurodevelopmental problems and thyroid illness.
Low ranges of fluoride are typically thought-about secure and key to stopping cavities. Amaechi says there is no concrete proof about potential harms of fluoride in relation to kids’s IQ. And analysis that has discovered associations between fluoride and IQ has checked out very excessive ranges of fluoride — over twice what’s advisable within the U.S. water provide. The CDC beforehand named the addition of fluoride to public ingesting water one of many high 10 nice public well being achievements of the twentieth century, alongside vaccinations and household planning. Additionally they say fluoride in water reduces cavities by 25%.
Nonetheless, Kennedy’s criticism of fluoride appears to have made its method to toothpaste — and opened up area for merchandise that use hydroxyapatite as an alternative.
So what’s hydroxyapatite?Â
The hype round hydroxyapatite is, partially, as a consequence of its similarity to tooth enamel. There’s additionally some analysis that implies hydroxyapatite may also help with tooth sensitivity.

Tooth enamel is generally manufactured from calcium and phosphate. These minerals kind the outer layer of your tooth, which protects the inner layers of tissues, nerves and blood vessels, from injury.
Your enamel is stronger than your bones, however nonetheless vulnerable to wreck over time from issues like sugary meals and dental plaque. Micro organism in your mouth feed on sugars, and produce acids that eat away on the outer layer of your tooth. Tenuta says over time, that course of units the stage for tooth decay, also known as caries, or ultimately cavities (a gap in a tooth that comes from this decay).
She says fluoride toothpaste helps shield tooth by “remineralizing” them with calcium and phosphate.
“When [fluoride is] obtainable in our saliva, within the dental plaque that we weren’t very good in brushing, that fluoride that’s left over after brushing with the fluoride toothpaste will really convey minerals again to the tooth,” Tenuta says.
Fluoride works with these minerals to kind a brand new compound that protects tooth. It acts like a protect in your enamel. However it’s essential brush with fluoride toothpaste persistently. Dentists advocate twice each day to maintain these minerals round in our mouths.
Hydroxyapatite is assumed to work in a barely totally different approach. These merchandise appear to get into tiny crevices within the tooth enamel.
Many hydroxyapatite merchandise use a kind known as nano-hydroxyapatite, which has smaller particles that, in principle, can extra simply penetrate pores in enamel, although analysis knowledge is proscribed.
The proof
Amaechi, who research hydroxyapatite use, says fluoride is extensively researched, particularly in long-term research. However he says early analysis on hydroxyapatite is optimistic.

“In the case of remineralization and stopping caries manifestation, it’s as efficient as fluoride,” Amaechi says.
Amaechi was an creator on a 2021 research within the journal Scientific Stories, that adopted 177 kids for nearly one yr, and in contrast hydroxyapatite toothpaste to fluoride toothpaste. The researchers tracked tooth decay in every group, and located that each teams had comparable outcomes. That research included funding from Dr. Wolff Group, a German firm that owns two manufacturers that make hydroxyapatite toothpastes.
That firm contributed funding to a different research, revealed two years later within the journal Frontiers in Public Well being. Researchers discovered comparable outcomes after monitoring 171 adults, evaluating tooth decay in members utilizing a hydroxyapatite toothpaste to these utilizing a fluoride toothpaste for 18 months. Each teams confirmed comparable outcomes, suggesting that hydroxyapatite labored in addition to fluoride within the research. Nevertheless, the members within the research had been largely wholesome younger adults with none extreme oral well being issues.
Tenuta says she’d wish to see extra long-term research, particularly in folks with excessive danger of tooth decay.
“There are only a few research and so they recruited members of low caries danger,” she says.
One shorter-term research in 2019, revealed within the Journal of Investigative and Medical Dentistry, did evaluate a hydroxyapatite toothpaste to fluoride toothpaste in 133 individuals who had been at larger danger of caries. After a little bit over 5 months, the researchers discovered each toothpastes carried out equally.
The underside line
Hydroxyapatite toothpastes are usually dearer than fluoride ones — some over a greenback dearer per ounce.
For sufferers who’re open to each choices, “I’ll advise them to make use of fluoride as a result of fluoride has extra proof supporting its efficacy,” Amaechi says.
Tenuta agrees.

“I might advocate as a best choice to stay to a fluoride toothpaste as a result of that is what we have now lots of proof behind,” she says.
The American Dental Affiliation, an expert group for dentists, stated in an e-mail to NPR they acknowledge extra individuals are utilizing merchandise with types of hydroxyapatite and that some proof suggests these merchandise can contribute to remineralization.
Nevertheless, analysis on the ingredient is new, “and proof concerning its medical effectiveness stays restricted and ambiguous, particularly concerning medical indications,” wrote ADA Client Advisor spokesperson Dr. Ada Cooper.
As a substitute, the ADA recommends you sweep your tooth twice a day for 2 minutes with a fluoride toothpaste, floss each day and usually go to a dentist.